Zurich is the most expensive city on this list and the one that most rewards visitors who understand what they're paying for. The Swiss do quality with a precision that is essentially religious — the espresso at the counter of any café, the bread at any bakery, the tram network that runs to the second, the way the lake (the Zürichsee) extends south into a perfect Alpine panorama on clear days. The old town (Altstadt) on both banks of the Limmat river has medieval guild houses, Romanesque churches, the finest art museum in Switzerland and a restaurant and bar scene that has genuinely arrived in the past decade. For those who find it excessive: the lakes, mountains and medieval villages of the surrounding canton are accessible in under an hour.
From London it's under two hours — Swiss, Easyjet and British Airways fly direct from Heathrow, Gatwick and City. Zurich Airport is 12km from the centre (direct train, 10 minutes, CHF 7). Go from May to September for the lake swimming and the outdoor restaurant terraces; December for the finest Christmas market in German-speaking Europe (at the main station — a genuine institution). The Sechseläuten spring festival (April) and Street Parade (August techno festival, one million people) are both worth knowing about.