Genoa is Italy's most overlooked major city and one of its most rewarding — a place that doesn't try to please you and is better for it. The caruggi (medieval alleyways) of the historic centre form the largest medieval urban fabric in Europe, a UNESCO World Heritage Site of extraordinary density: five-storey stone buildings that block out the sky, sudden piazzas opening in the dark, chapels and palazzi at every corner. The Palazzi dei Rolli — the Renaissance palaces of Genoa's merchant aristocracy, also UNESCO-listed — are the finest collection of 16th-century domestic architecture in Italy. Genoa gave the world Christopher Columbus, pesto alla Genovese, focaccia and the shipping container. The Cinque Terre are 90 minutes by train.
From London it's just over two hours — Ryanair flies from Stansted to Genoa Cristoforo Colombo Airport; easyJet from Gatwick. The airport is 6km from the centre (Volabus, 25 minutes, €6). Go from April to June or September to October — the heat is manageable, the caruggi are cool and the Ligurian Riviera is at its finest. July and August are very hot; Christmas brings one of Italy's finest presepe (nativity scene) traditions to the city's churches.